WebMay 1, 1996 · Chemistry. Chemistry Letters. Regiospecific N- or C-benzylations of 2-pyridone are observed in solvent-free conditions in the absence of base. The regioselectivity is controlled by the heating technique (microwave irradiation or conventional heating) or, using microwaves, by the emitted power or the leaving group of benzyl halides. WebP Shanthan's 3 research works with 161 citations and 1,676 reads, including: Synthesis and biological evaluation of novel N1-decyl and C7- Sec amine substituted fluoroquinolones as antitubercular ...
Solvent-Free Benzylations of 2-Pyridone. Regiospecific N- or C-Alkylation
WebDec 8, 2024 · A visible-light-promoted O–H insertion reaction between 2-pyridones and α-aryldiazoacetates has been developed. Upon visible light irradiation, the reaction proceeds smoothly under mild and catalyst-free conditions. A wide scope of 2-pyridones and α-aryldiazoacetates are well tolerated, and various O-alkylat Synthetic methodology in OBC WebSep 1, 2024 · Here we show that although 2-chloroacetamide reduces the level of off-target alkylation, it exhibits a range of adverse effects. The most significant of these is methionine oxidation, which increases to a maximum of 40% of all Met-containing peptides, compared with 2-5% with iodoacetamide. Increases were also observed for mono- and dioxidized ... high speed nand
Regioselective O-alkylation of 2-pyridones by TfOH-catalyzed
WebReacting quinolinols and isoquinolinols under Mitsunobu conditions can give rise to N-alkylated products in addition to the normally desired O-alkylated structures. An in-depth … WebOct 13, 2010 · N-Alkylation vs O-Alkylation: Influence on the Performance of a Polymeric Field-Effect Transistors Based on a Tetracyclic Lactam Building Block. Macromolecules … WebIn all cases, the guest molecules are hydrogen bonded to the host molecules through O-H...O=C hydrogen bonds [the range of O...O distances is 2.543 (2)-2.843 (2) A. The pyridone moieties form dimers through N-H...O=C hydrogen bonds in five of the compounds [the range of N...O distances is 2.763 (2)-2.968 (2) A]. high speed nas