Neoplastic clone
WebFeb 17, 2024 · Although karyotyping may ideally describe all chromosome aberrations of the neoplastic clone, with the exception of some cryptic translocations, the amount of proliferating cells that are required ... Web-Although the presence of an abnormal clone usually indicates a malignant neoplastic process, in rare situations, the clone may reflect a benign condition. -The absence of an …
Neoplastic clone
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WebJun 4, 2024 · The regions of the BMZ beneath growing clones of pre-neoplastic cells are of considerable interest because these are the regions where the BM becomes eroded on tumor invasion. In the larval cancer models, as pre-neoplastic clone diameter increases to 30–50 μm, individual holes beneath them begin to coalesce (Figure 4 D). WebOct 31, 2024 · We have also detected multiple neoplastic clones in the peripheral blood in all examined patients. Based on these findings, we propose that circulating neoplastic T-cell clones continuously replenish the lesions of MF, thus increasing their heterogeneity by a mechanism analogous to the consecutive tumor seeding.
WebMar 23, 2015 · In this paper we present VDJSeq-Solver, a methodology and tool to identify clonal lymphocyte populations from paired-end RNA Sequencing reads derived from the sequencing of mRNA neoplastic cells. The tool detects the main clone that characterises the tissue of interest by recognizing the most abundant V(D)J rearrangement among the … WebAssessment of Clonality in Lymphoma and Leukemia. A clonality assay demonstrates that a group of cells is derived from a single clone. The term is usually used to refer to detection of the unique genes found in each individual B- or T-cell—immunoglobulin genes in B-cells and T-cell receptor (TCR) genes in T-cells.
WebOct 31, 2024 · Even in the early stages of the disease, patients have circulating neoplastic T-cell clones in peripheral blood. Early lesions are initiated by the pioneer clones and create a niche (blue-shaded area) that facilitates seeding of this area of the skin (lesion 1) with subsequent clones (lesion 2) (consecutive seeding model 43 and supplemental ... WebIf the general process by which sporadic colon cancers arise is the formation of a pre-neoplastic clone that spreads by natural selection, followed by formation of internal sub-clones within the initial clone, and sub-sub-clones inside those, then colon cancers generally should be associated with, and be preceded by, fields of increasing ...
WebJan 31, 2013 · Neoplastic clones would thus include those that never evolve further, as well as those that eventually give rise to fully malignant populations, and all stages in between. The term cancer stem cells would then be more appropriately restricted to cells generating subclones that have established malignant properties.
WebThe neoplastic clone and its differentiated progeny are also the main source of an indirect paracrine secretion of inflammatory cytokines released by different normal cells present … netherlands laceWebFeb 17, 2024 · Although karyotyping may ideally describe all chromosome aberrations of the neoplastic clone, with the exception of some cryptic translocations, the amount of … netherlands ladies footballWebJan 29, 2024 · As normal cells with better chromosome morphology may be present, it is important to analyse cells of varying quality in order to maximise the likelihood of detecting a neoplastic clone. netherlands ladies football teamWebJun 4, 2024 · The regions of the BMZ beneath growing clones of pre-neoplastic cells are of considerable interest because these are the regions where the BM becomes eroded on tumor invasion. In the larval cancer models, as pre-neoplastic clone diameter increases to 30–50 μm, individual holes beneath them begin to coalesce (Figure 4D). netherlands la giWebOct 23, 2013 · However, the detection of the Rh splitting clone and its quantification over time, might offer some indications on the disease evolution or on the response to therapy. Myeloproliferative neoplasms are evolutive diseases, in which the neoplastic clone progressively acquires additional genetic changes, often evidenced only by sophisticated … ityt.comWebOct 19, 2015 · A clone was detected in both samples that was identical in amplicon size. This case was presented at a multidisciplinary tumor board conference. While the … netherland slangWebJul 9, 2024 · The aim of this review is to provide an integrated clinical and biological overview of high-risk MM, discussing novel therapeutic perspectives, targeting the neoplastic clone and its microenvironment. netherlands land reclamation