Canine model of pacing-induced heart failure

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August undefined, 2024

WebDec 1, 2010 · Canine model of pacing-induced HF. All animal study protocols were approved by the Institutional Animal Care and Use Committee of Indiana University … WebIn studies aimed at characterizing the canine pacing-induced heart failure model further, it was demonstrated that atrial ERP was unchanged prior to the initiation of AF (Li et al., 1999). The extent of atrial fibrosis, however, was increased dramatically (from 0.3% in control to ∼15% in animals in congestive heart failure), a structural ...

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WebMar 19, 1999 · Pacing-induced heart failure in the dog recapitulates many of the electrophysiological and hemodynamic abnormalities of the human disease; however, the mechanisms underlying altered Ca2+ handling have not been investigated in this model. how to roll out sculpey clay

Global and regional wall motion abnormalities of pacing-induced heart ...

WebJul 10, 2024 · Pacing-induced heart failure in the dog recapitulates many of the electrophysiological and hemodynamic abnormalities of the human disease; however, the mechanisms underlying altered Ca2+ handling ... WebJun 1, 1999 · In the canine pacing model, we first reported the appearance of interstitial edema and disruption/disappearance of collagen fibers in the hearts of these animals as … WebCanine model of pacing-induced HF. All animal study protocols were approved by the Institutional Animal Care and Use Committee of Indiana University School of Medicine … how to roll out frozen bread dough

(PDF) Intracellular calcium dynamics and acetylcholine-induced ...

WebThis model typically produces heart failure as defined by an LV dP/dt max <1500 mmHg/s, end-diastolic pressure >25 mmHg, mean arterial pressure <85 mmHg, and an ejection … WebMyocardial Akt levels were elevated in early heart failure (after 1-2 weeks of pacing) accompanied by increased levels of oxidative stress, cytokine tumor necrosis factor-alpha (TNF-alpha) and free fatty acid accumulation, reduced activity levels of mitochondrial respiratory complexes III and V and apoptosis initiation. how to roll out of 99 wowWebFeb 18, 2014 · In addition, a model of pacing-induced heart failure was employed to examine conditions of CHF and the results may be different in heart failure of a different origin. Conclusion. The present data demonstrate for the first time that a fast phase-III repolarization was associated with a low proarrhythmic potential in CHF, whereas a more … how to roll out it band

"WebTachypacing-induced heart failure is a well-established large animal model that recapitulates numerous pathophysiological, structural and molecular features of dilated … " - Canine model of pacing-induced heart failure

Canine model of pacing-induced heart failure

A new mechanism preventing proarrhythmia in chronic heart failure ...

WebJul 10, 2024 · The development of pacing-induced heart failure was studied in chronically instrumented, conscious dogs paced at a rate of 240 beats/min for 1 d (n = 6), 1 wk (n = … WebWhile these results suggest uniform K Ca 2 remodeling during AF, a more complex picture with species- and mechanism-based remodeling of the channels is supported by data obtained from a canine model of AF induced by 7 days atrial tachypacing. 11 In dogs, left atrial K Ca 2.1 channel protein was increased without changes in the corresponding mRNA.

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WebMar 20, 2001 · The canine pacing-induced heart failure model shows a pattern of E-C coupling changes similar to that of humans: I Ca,L of normal amplitude triggers Ca i transients and contractions much smaller than normal, whereas SR Ca uptake is markedly impaired. 11 The present study investigates whether the defect in E-C coupling is due to … WebDec 4, 2014 · In dogs with heart failure induced by 6 weeks of atrial tachy- pacing, PITA (starting on week 3) suppressed progressive cardiac …

WebThe most well-characterized large animal model of DCM is the pacing induced tachycardia model. 35–44 First described by Whipple et al 35 … WebFeb 18, 2014 · Some patients even develop severely depressed LV function within a short time frame, a condition that has been coined ‘dyssynchronopathy’ in a canine model of AV block that develops rapid heart failure. 10 Development of a dyssynchronopathy might also explain the well-known but ill-defined group of super-responders to CRT. 11 It should be ...

WebThe LVEDP increased and impedance decreased during pacing-induced heart failure and recovered after pacing cessation. At the end of pacing, there was a mean impedance reduction of 10.6 +/- 8.3% and a mean LVEDP increase of 18.1 +/- 4.5 mmHg compared to baseline. The impedance and LVEDP were inversely correlated (r =-0.41 to -0.85, all P < … WebApr 12, 2024 · Liu et al. used a rapid pacing model in vitro and a canine model of rapid pacing to establish the implication of miR-23a-3p in ferroptosis during AF. ... Yanni et al. used an animal model of heart failure that developed sinus bradycardia to demonstrate the function ... Lower levels of cardiac fibrosis are clinically associated with drug-induced ...

WebJun 13, 2005 · Animal Model Preparation. All procedures were approved by the Indiana University Institutional Animal Care and Utilization Committee. The study was performed in a canine model of healed myocardial infarction (MI) and pacing-induced heart failure (HF) that was shown to have a high incidence of spontaneous ischemic ventricular …

WebThe aim of the study was to use the isolated blood-perfused rat heart to: (i) determine whether brief intermittent rapid pacing and ventricular fibrillation ar 掌桥科研一站式科研服务平台 how to roll out pizza dough videoWebThe mechanisms of sinoatrial node (SAN) dysfunction in heart failure (HF) remain unclear. We hypothesized that impaired rhythmic spontaneous sarcoplasmic reticulum Ca(2+) … northern ireland b and bWebTachypacing-induced heart failure is a well-established large animal model that recapitulates numerous pathophysiological, structural and molecular features of … how to roll out pastaWebJul 1, 2024 · The cardiac effects of pimobendan (but not amrinone) are preserved at rest and during exercise in conscious dogs with pacing-induced heart failure. J Pharmacol Exp Ther. (1997) 282:23–31. PubMed Abstract Google Scholar. ... 34. Powers JC, Recchia F. Canine model of pacing-induced heart failure. Methods Mol Biol. (2024) … how to roll out pretzel doughWebAug 21, 2010 · Second, we used a pacing-induced heart failure canine model to observe the global and RWM abnormalities after long-term (2 months) rapid pacing (180/min). The patient and canine results were compared to see if the canine model reproduced the findings in patients. northern ireland bdm indexWebAtrial fibrillation (AF) is commonly associated with congestive heart failure (CHF), and CHF has been shown to be associated with atrial structural remodeling resulting in fibrosis. Atrial interstitial fibrosis has been seen in patients with CHF and in animal models of pacing-induced heart failure. … how to roll out of bed after back surgeryWebBackground Heart failure increases autonomic nerve activities and changes intracellular calcium (Ca i ) dynamics. Objective The purpose of this study was to investigate the hypothesis that abnormal Ca i dynamics are responsible for triggered activity in the pulmonary veins (PVs) during acetylcholine infusion in a canine model of heart failure. northern ireland bank of ireland